Original Research Paper
RELATIONSHIP BETWEEN MATERNAL VITAMIN D DURING PREGNANCY AND RISK OF PRETERM BIRTH
Background: Preterm birth is the leading cause of death among neonates and children under 5 years of age with long term adverse sequelae in the survivors. Vitamin D is being increasingly researched for its protective effect against the risk for preterm births due to its role in immunmodulatory and anti-inflammatory processes. An observational study was undertaken to study the relationship between maternal serum vitamin D levels during peripartum period and the risk for preterm birth. Methods: This study employed a cross sectional design in a tertiary care centre on 569 patients to study the relationship between maternal serum vitamin D levels and risk of preterm births. Results: A total of 569 samples of maternal and neonatal serum were analyzed for serum 25(OH)D levels. 464 (81.54%) mothers had Vitamin D sufficient (VDS) levels 30ng/ml and 105 (18.45%) had vitamin D deficient (VDD) levels <30ng/ml. Out of the total of 569 deliveries, 501(88.04%) occurred at term (37 weeks period of gestation) and 68 (11.95%) were preterm (<37 weeks period of gestation). The incidence of preterm births was 10.77% in the vitamin D sufficient group as compared to 17.14% in the vitamin D deficient group (p=0.038). The mean cord blood 25(OH)D level of preterm neonates was 12.68ng/ml(SD 3.85, range 7.9-22) and term neonates was 13.63ng/ml(SD 3.76, range 8.2-27) (p=0.038).Conclusion: The rate of preterm delivery was 1.59 times higher in mothers with vitamin D deficiency. Also, the mean cord blood vitamin D levels were higher in newborns born at term.
Keywords :Vitamin D deficiency Preterm Newborn Cord blood vitamin D.
Cite This Article:
RELATIONSHIP BETWEEN MATERNAL VITAMIN D DURING PREGNANCY AND RISK OF PRETERM BIRTH, Dr. Gurpreet Kaur Dhillon, Dr Sunil kumar Rai, Dr. Harpreet Singh Dhillon, Dr. Shibu Sasidharan, INTERNATIONAL JOURNAL OF ADVANCED MEDICINE : Volume-4 | Issue-5 | September-2020
[ Download PDF ] [ Number of Downloads : 50 ]