Comparative evaluation of serum Alpha-1 antitrypsin levels in patients with Oral Squamous Cell Carcinoma and in healthy subjects with and without tobacco habit.
Aim/ Objectives: To evaluate serum levels of Alpha 1 anti trypsin in patients with oral squamous cell carcinoma and to compare them with that of healthy subjects with and without tobacco habits.Material and Method: The sample of 83 subjects was divided into 3 groups; 30 subjects with OSCC formed Group A. The age, sex, habit matched 23 healthy subjects with tobacco habit formed group B and 30 healthy without history of consumption of tobacco, formed group C. Analysis of the samples was done using Alpha 1 anti trypsin kit and spectrophotometer.Results: There was a 2.33 fold rise in serum levels of Alpha 1 anti trypsin in Group A as compared to Group B, 3.71 fold rise in Group A as compared to Group C and 1.59 fold rise in Group B as compared to Group C (p < 0.001). A definite rise in serum Alpha 1 anti trypsin levels in patients with oral squamous cell carcinoma as compared to healthy subjects with and without tobacco habits was observed.Conclusion: A1-AT can be used as an adjunct to various diagnostic procedures implied for the evaluation of OSCC.
Keywords :Alpha-1 antitrypsin Oral squamous cell carcinoma Spectrophotometry Tobacco
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COMPARATIVE EVALUATION OF SERUM ALPHA-1 ANTITRYPSIN LEVELS IN PATIENTS WITH ORAL SQUAMOUS CELL CARCINOMA AND IN HEALTHY SUBJECTS WITH AND WITHOUT TOBACCO HABIT., Dr. Upasana Sethi Ahuja, Dr. Nidhi Puri, Dr. Anjana Bagewadi, Dr. Vaishali Keluskar, Dr. Anshuman Ahuja, INTERNATIONAL JOURNAL OF ADVANCED MEDICINE : Volume-2 | Issue-4 | July-2018
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