Original Research Paper

A Comparative Study Of Inflammatory Marker Highly Sensitive C-reactive Protein Between Depression Patients With Suicidal Attempt And Depression Patients With Suicidal Ideation

Abstract :

Background: Suicidal ideation and attempt in context of depression is very common. Many studies have demonstrated an association between suicidal behaviour and inflammatory markers primarily CRP. We explore a clinical inflammatory marker (CRP) in psychiatric patients hospitalized in an acute adult inpatient facility following suicidal attempt and ideation Aims: To compare hsCRP levels between depression patients with suicidal attempt and suicidal ideation. Methodology: Comparison of 25 depression patients with suicidal attempt and 25 depression patients with suicidal ideation was done, diagnosis as per ICD10. Hamilton Depression Rating Scale (HDRS17), Beck Scale for Suicidal Ideation (BSSI), Suicide behaviour Questionnaire- Revised (SBQ-R), were applied for assessment of depression and suicidality. Highly sensitive CRP was measured using autoanalyzer. Results: hsCRP levels were significantly high in depression patients with suicidal attempt (6.11 mg/dl) than depression with suicidal ideation (2.14 mg/dl). Duration of illness, HAM-D, BSSI & SBQ-R scores correlated positively with hsCRP levels. Conclusion: Depression with suicidal attempt patients demonstrated a statistically higher hs-CRP levels than depression with suicidal ideation. Patients of depression with suicidal attempt have a strong positive correlation between hs-CRP levels and HAM-D, BSSI & SBQ-R scores.

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