Original Research Paper

Clinical And Biochemical Profiling Of Low Body Weight Diabetic Mellitus Type 2 Patients With Special Emphasis On Echocardiographic Changes

Abstract :

Aims and objective: To study the clinical and biochemical profile of low body weight type 2 diabetes mellitus (BMI<19 kg/m2). To study the prevalence of echocardiographic abnormalities in low body weight diabetes mellitus type 2 patients and compare with non-lean type 2 diabetes. To compare microvascular & macrovascular complications in low body weight diabetes mellitus 2 and non lean diabetes mellitus type 2 patients.Materials and Methods: This study was a hospital based cross-sectional study conducted in M.L.B.Medical College, Jhansi (U.P.). In this study,100 low bodyweight type 2 diabetic patient were selected for the study coming to OPD and IPD of Internal Medicine Department, M.L.B Medical College, Jhansi (U.P.), during March 2019Sept. 2020. The clinical, biochemical profile and echocardiographic study was done in these patients.Result: A total of 100 low body weight type 2 diabetes mellitus patients (BMI<19kg/m2) were studied. The study of biochemical profile in the low body weight type 2 DM patients showed poor glycemic control with mean HbA1C of 8.94. The lipid profile in these patients was well within normal range in majority of the patients. The prevalence of microvascular complications like peripheral neuropathy (seen in 65% of patients)was higher as compared to macrovascular complications like Coronary Artery Disease and Hypertension in low body weight type 2 diabetes patients. The majority of these patients revealed normal cardiac function (85% of total) and 15% of patient showed mild concentric LV Hypertrophy and grade 1 diastolic dysfunction and mean Carotid media intima thickness was well within normal range for the same age control group.Conclusion: The study of biochemical profile in low body weight type 2 diabetes mellitus patients concluded that mean HbA1C was higher in these patients with poor glycemic control. This study concluded that prevalence of microvascular complication was higher in low body weight type 2 diabetes mellitus patients as compared to the macrovascular complication. An abnormal echocardiography finding was found in 15% of the total study patients who had mildhypertrophy and grade I diastolic dysfunction as compared to 49.8% as seen in non lean type 2 diabetes mellitus patients.

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