Research Paper

The Therapeutic Effects Of Taurine Against Hepatotoxicity Induced Through Carbon Tetra Chloride In Rats

Abstract :

The present study explores the protecting functions of Taurine on lipid-peroxidation and antioxidant enzymes activity in Carbon tetrachloride induced liver fiosis and cirrhosis in experimental rat models. Study included 24 age matched male Albino Wistar rats divided (n=6) into; Group I =healthy untreated rats, Group II & III = CCl4 in a dose of 0.8 ml/Kg body weight, subcutaneously two times per week for 60 days, group III & IV= in addition received1% w/v taurine in drinking water daily for 8 weeks. Biochemical investigations included MDA, bilirubin, hepatic and antioxidant enzymes. CCl4 produced liver toxicity as shown by increased total bilirubin, hepatic enzymes (SDH, ALT, ALP & AST) and MDA concentrations while decline in activity of antioxidant enzymes; catalase, GSH, SOD, PON-1 & CP. Taurine supplementation in rats noticeably reduced the levels of AST, ALT, ALP, total bilirubin & SDH and resumed the levels of Catalase, GSH, SOD, MDA, PON-1 & CP. The histopatholologic findings showed mild portal and periportal inflammatory changes and fiosis alongwith degenerated hepatocytes rats treated with CCl4. Rats treated with taurine along with CCl4 showed slight periportal fiosis without degenerated hepatocytes suggesting that taurine mitigates the liver toxicity created by CCl4 in rats.

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