Original Research Paper

A Study Of Thyroid Functions In Patients With Chronic Kidney Disease

Abstract :

Chronic kidney disease is the final common pathway of irreversible loss of nephrons finally resulting in alteration of milieu interior affecting every system in the body including thyroid hormonal system. The aim of this study was to evaluate thyroid functions in patients with chronic kidney disease. Material and method: This cross sectional study was conducted on 100 patients, who was diagnose to have chronic kidney disease and on conservative management, being admitted in Department of Medicine, JLN medical college & hospital, Ajmer, during the period of Oct. 2018 to April 2020. Detailed history and investigations were done. Quantitative determination of T3, T4 and TSH was done by Enzyme Linked Immunosorbent Assay. Result: Age ranges from 18-68years. Male patients were predominating accounting 68% and female patients were accounting32%.Duration of chronic kidney disease symptoms ranges from 4 months to 30months. Creatinine clearance ranges from 6ml/min 32ml/min. Blood urea values varied from 45-184mg/dl, the mean being 102.12. Serum creatinine levels varied from 214mg/dl, the mean being 7.34. Serum calcium level found to be low in 20 patients, normal in 56 patients and high in 24 patients. Serum phosphorous level found to below in 24 patients and remaining 76 patients are in normal range. The study range of serum T3 was 0.22.0ng/ml, the mean being 0.67 (normal range 0.62.1ng/ml), serum T4 was 0.98.5g/dl, the mean being 5.65 (normal range 5-13g/dl) and serum TSH was 0.638IU/ml, the mean being 6.49 (normal range 0.4-5.6IU/ml) In this study 58% patients had low T3 syndrome, 24% patients had low T4 syndrome and 8% patients had hypothyroidism. Conclusion: Thyroid function tests investigations will provide new insights in our understanding of the biological significance of thyroid hormone changes in patients with kidney diseases.

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