Original Research Paper

A Study Of Residual C-peptide Level (fasting And Post Ogtt) In Type -1 Diabetes Population & It's Correlation With Duration Of Diabetes And Antibody Status In A Tertiary Care Centre In Eastern India

Abstract :

Type 1 diabetes is a disorder resulting from chronic autoimmune destruction of pancreatic beta cells. As far as the conventional understanding of Type 1 diabetes goes, beta cells of pancreas are destroyed almost completely at the symptomatic disease onset. Only 10% of beta cells remain in the stage of overt diabetes during pre-symptomatic period and thereafter these beta cells are destroyed within one year of symptomatic disease onset(1). In contrary, the current model of Type 1 diabetes shows that certain amount of functioning beta cells remain in varying proportion in all individuals with Type 1 diabetes, even as long as for 40 years duration(2-5). The amount of residual beta cells is indirectly measured by measuring serum C- peptide level in fasting state as well as after stimulation either by OGTT or mixed meal or Glucagon injection (6-8). The studies have shown that this proportion of residual beta cell activity could be associated with improved metabolic outcome, reduced insulin dose requirements and reduced incidence of diabetes related complications (9-16). However, the studies are less in our country.

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