Research Paper

Cardiac Dysfunction In Patients With Hypothyroidism In Adults.

Abstract :

BACKGROUNDHypothyroidism is a graded disorder and its cardiovascular effects need further exploration.METHODSIn this prospective case control study, we evaluated, 50 newly diagnosed hypothyroid patients and 25 age and sex matched controls, attending a tertiary care centre of North India for cardiac dysfunction. Statistical analysis was done using SPSS (statistical package for social sciences) software.RESULTSHypothyroid patients had significant dyslipidaemia than controls. Though, the in-group difference for 10-year ASCVD risk score was statistically insignificant (4.81 5.75 vs 3.66 3.50; p = 0.36). On echocardiography, Interventricular septal wall thickness and Left ventricular posterior wall thickness and LVEDD were significantly increased. Also, significant number of patients had Diastolic Dysfunction, mean E/A ratio (0.90 0.16 vs 1.02 0.10; p = 0.001). No significant LV Dysfunction or RWMA was noted. CONCLUSIONThe cardiovascular changes and dyslipidaemia were more marked in hypothyroidism compared to controls.

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