Original Research Paper

Systematic Review Of Efficacy, Immunogenicity Dosing Schedule, Technological Platform And Safety Of Covid-19 Vaccine

Abstract :

Introduction: SARS-CoV-2 was first identified in Wuhan, China in early December 2019, it is responsible COVID-19 pandemic. Currently different platforms of vaccines such as; inactivated whole virus, live-attenuated virus and protein subunit of the virus, next-generation technique including m RNA, viral vector-based technology are used. The aim of this study is the systematic review of COVID 19 vaccines s efficacy and side effects. Methods:We reviewed the literature from various databases from Feuary to May 2021. We have used these key words for search in databases: Corona virus, SARS-CoV-2, COVID-19 pandemic, vaccine, efficacy, side effect. No limitations on public status, study design were imposed. We had just language limitations , also, the PICO framework was applied in literature review. All papers on efficacy of COVID vaccines were selected and entered in this review study. Two reviewers independently extracted the data, any disagreement in opinion was resolved by consensus in agreement with a third reviewer. Data were extracted from published papers. Data were checked for study characteristics duration, pharmaceutical company, and type of COVID vaccine, immunization schedule, dosage, and route of administration, number, age of participants. Results: the efficacy of COVID vaccine was 50.4% to 95% , and the most common side effect of vaccine was: pain, redness, swelling, fever, fatigue, headaches, muscle pain, nausea, vomiting, itching, and rarely complications such as; thrombosis, thrombocytopenia, anaphylactic shock. Conclusion: In conclusion, immunization is helping to control the pandemic by reducing viral spread and severity of symptoms.

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