Original Research Paper

Study Of Relationship Between Acute Coronary Syndrome And Total Bilirubin Level.

Abstract :

Background: The most common cause of mortality in the developed nations is cardiovascular disease (CVD) which accounts for up to one-third of all deaths in the world. The expeditious diagnosis of acute coronary syndrome (ACS) is lifesaving. Bilirubin was considered to be a toxic waste product of the heme oxygenase action but now among various boons, including antioxidant property, it is found to have a strong relation with acute coronary syndrome (ACS). The present study was undertaken to evaluate the association between bilirubin and ACS by comparing it with a control group. Methods: Institutional ethical clearance was obtained prior and informed consent was obtained from patients. A detailed history, general physical examination, systemic examination and investigations were performed on all patients who fulfilled the inclusion criterion. Controls were selected and matched with gender and other co-morbid conditions. The correlation between serum bilirubin and ACS was evaluated. Results: Hypertension had statistically significant correlation with ACS. All risk factors were more associated with STEMI compared to unstable angina or NSTEMI. LDL and total leucocyte count with bilirubin both were statistically significant when compared to bilirubin levels. Conclusion: The evidence presented in this study favours the notion that bilirubin, via its antioxidant potential, possesses anti-atherogenic properties. A significant inverse relationship was established between serum bilirubin and ACS. A higher level of serum bilirubin within the physiologic range plays a protective role against incident CVD.

Cite This Article:

References :