Original Research Paper

The Role Of Platelet To Lymphocyte Ratio And Neutrophil To Lymphocyte Ratio As Non-invasive Markers Of Mucosal Activity In Ulcerative Colitis At A Teritiary Care Hospital In Tamil Nadu

Abstract :

Background:Economical and readily available biomarkers for assessing Ulcerative colitis are need of the hour,for this purpose we evaluated platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in patients with ulcerative colitis.Methods:We analyzed 48 patients with UC who underwent measurement of fecal calprotectin (FC) and endoscopy and 96 matched healthy controls. NLR and PLR were compared between the patients and healthy controls. The endoscopic activity was divided into 2 groups: group 1 (mild to moderate inflammation) and group 2 (severe inflammation) according to the Mayo endoscopic score in UCResults:To diagnose UC,the optimal cutoff of NLR and PLR was 2.26(sensitivity 54.2%; specificity 90.6%)and 179.8(sensitivity 35.4%; specificity 90.6%) respectively. The optimal cut off to differentiate group 1 and group 2 was 3.44, 175.9, and 453 g/g for NLR,PLR, and FC,respectively (sensitivity, 63.6% vs. 90.9% vs. 81.8%; specificity, 81.1% vs. 78.4% vs. 73.0%; positive likelihood ratio,3.364 vs. 4.205 vs. 3.027; AUC, 0.714 vs. 0.897 vs. 0.813). PLR had the highest AUC and positive likelihood ratio.Conclusion:NLR and PLR are useful in patients with UC from healthy controls. NLR, PLR, and FC may reflect intestinal mucosal conditions.

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