Research Paper

Association Of Maternal Obesity, Birth-weight, Insulin Levels And Homa-ir In Newborns At Term In A Tertiary Care Centre

Abstract :

Introduction: Intrauterine environment which represents a time when changes in metabolism may affect distant metabolic dysfunction in the offspring mediated through physiological and epigenetic mechanism. Maternal pregravid weightBMI was associated with increased birth weight and insulin resistance in neonates. Maternal obesity and underlying insulin resistance are significant short and long-term risk factors for both the mother and her fetus which creates the potential of a vicious cycle of obesity & insulin resistance and development of diabetes in later life. AIM: The objective of the study was to evaluate the association of maternal pregravid obesity with birth-weight and HOMA-IR in newborns at term. Materials and Methods: This is a prospective study for a period of one year from Dec.2010 to Nov.2011. Neonates of Forty lean (BMI < 25 kg/m2) and forty obese women (BMI > 30kg/m2) with singleton term pregnancy were evaluated at elective cesarean section over a period of one year. Results: There was a positive relationship between maternal pregravid BMI, birth-weight and newborns insulin resistance (r = 0.438, p = 0.0001).

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